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Groupe Développement des circuits neuronaux

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Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

neural circuits
zebrafish
Optogenetics
behavior
Vision
Available to host a PhD student

Labelisation ENP: 

2012

Centre de recherche / Institut: 

Institut Curie - Centre de Recherche

Code unité de recherche: 

U934 - UMR3215

The optic tectum has emerged as a tractable visuomotor transformer, in which anatomical and functional studies can allow a better understanding of how behavior is controlled by neuronal circuits. We are examining the formation and function of the visual system in zebrafish larvae using in vivo time-lapse microscopy and state-of-the-art “connectomic” and “optogenetic” approaches to monitor and perturb neuronal activity. We apply complementary cellular and molecular analyses to dissect this circuit and identify the neuronal substrate of visual behaviors.

Leader

Leader: 

Personnel

Etudiants ENP: 

Membres de l'équipe: 

Karine Duroure
Thomas Auer
Christoph Gebhardt
Vincenzo Di Donato
Flavia De Santis
Celine Revenu
Shahad Albadri
Noe Testa
Établissements

Établissement de rattachement: 

Institut Curie

Établissements affiliés: 

CNRS
Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Virginie Bourgeois

Initiatives d'Excellence: 

Labex DEEP
Publications

publications: 

Dunn TW, Gebhardt C, Naumann EA, Riegler C, Ahrens MB, Engert F, Del Bene F. Neural circuits underlying visually evoked escapes in larval zebrafish Neuron Accepted

Auer TO, Xiao T, Bercier V, Gebhardt C, Duroure K, Concordet JP, Wyart C, Suster M, Kawakami K, Wittbrodt J, Baier H, Del Bene F. Deletion of Kinesin I motor unmasks a mechanism of homeostatic branching control by Neurtrophin-3. eLIFE 2015 Jun 15;4.

Auer TO, Duroure K, Concordet JP, Del Bene F CRISPR/Cas9-mediated conversion of eGFP into Gal4 transgenic lines in zebrafish. Nature Protocols 2014 Dec;9(12):2823-40.

Auer TO, Duroure K, De Cian A, Concordet JP, Del Bene F (2014) Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome research 24: 142-153

Del Bene F#, Wyart C#, Robles E, Tran A, Looger L, Scott EK, Isacoff EY, Baier H (2010) Filtering of visual information in the tectum by an identified neural circuit. Science 330: 669-673

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